Related Experiment Video
Updated: Aug 14, 2026

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
Published on: May 24, 2016
The effect of dantrolene sodium in Very Long Chain Acyl-CoA Dehydrogenase Deficiency
N C Voermans1, P J Poels, L A Kluijtmans
1Neuromuscular Center Nijmegen, Department of Neurology, 935 Radboud University Nijmegen Medical Center, P.O. Box 9101, the Netherlands. n.voermans@neuro.umcn.nl
Abstract:
We present a patient, who experienced recurrent episodes of rhabdomyolysis. Her beneficial response to treatment with dantrolene sodium was previously reported. Adult onset Very Long Chain Acyl-CoA Dehydrogenase (VLCAD) deficiency has been diagnosed only recently. In adults, VLCAD deficiency results in recurrent fasting-, exercise-, or infection-induced muscle stiffness, muscle pain and myoglobinuria caused by rhabdomyolysis. This case illustrates for the first time the beneficial effect of dantrolene in VLCAD deficiency. We discuss the therapeutic mechanism of dantrolene sodium and its possible role as additional treatment modality for patients with VLCAD deficiency.
Related Concept Videos
Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
The binding of dantrolene to the RYR1...
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Muscle Recovery and Fatigue
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Lysosomal Hydrolases

