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Effects of repeated in vivo inhalant nitrite exposure on gene expression in mouse liver and lungs
Doanh C Tran1, Daniel A Brazeau, Peter A Nickerson
1Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.
Abstract:
Exposure to inhalant organic nitrites (drugs of abuse commonly known as "poppers") has been reported to enhance tumor growth in mice, but the mechanism is not fully defined. This study examined the effect of repeated in vivo nitrite exposures on gene expression in the mouse liver and lungs using a gene array panel of 94 cancer- and angiogenesis-related genes. Using 2-fold change as a threshold criterion, repeated nitrite exposure was found to alter the expression of 65 and 23 genes in the liver and lungs, respectively. Six genes were significantly upregulated (p
