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Related Experiment Videos

To engineer is to create: the link between engineering and regeneration.

David F Williams1

  • 1UK Centre for Tissue Engineering, University of Liverpool, Liverpool, UK. dfw@liv.ac.uk

Trends in Biotechnology
|November 18, 2005
PubMed
Summary

Tissue engineering needs a systems engineering approach for true progress. Integrating all biological and technological phases, alongside systems biology, is key for clinical and commercial success in regenerative medicine.

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Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Systems Engineering

Background:

  • Tissue engineering offers novel reconstructive strategies for degenerative diseases and trauma.
  • Current clinical outcomes and commercialization of tissue engineering remain limited.
  • A fundamental misunderstanding of engineering principles as creation hinders progress.

Purpose of the Study:

  • To redefine tissue engineering through a systems engineering lens.
  • To emphasize the integration of all process phases in tissue engineering.
  • To explore the potential of systems biology in advancing tissue engineering.

Main Methods:

  • Critically analyze current tissue engineering paradigms.
  • Propose a shift from linear to integrated systems engineering approaches.

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  • Suggest the incorporation of systems biology principles.

    • Main Results:

    • Identified a lack of phase integration as a major bottleneck in tissue engineering.
    • Highlighted the necessity of viewing engineering as a creation process.
    • Proposed a holistic, systems-based framework for tissue engineering.

    Conclusions:

    • A systems engineering approach is crucial for advancing tissue engineering.
    • Full integration of biological and technological phases is required.
    • Superimposing systems biology onto systems engineering may unlock future success.