Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DES clinic--the first six months.

M Wingfield1, V S Donnelly, P Kelehan

  • 1National Maternity Hospital, Dublin.

Irish Medical Journal
|June 1, 1992
PubMed
Summary

A Dublin clinic for Diethylstilbestrol (DES) exposure saw 95 women in six months. While classical signs were present in 15, no cervical intraepithelial neoplasia or clear-cell adenocarcinoma were detected.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Faecal incontinence (Br J Surg 2007; 94: 134-144).

The British journal of surgery·2007
Same author

Nurse specialist led flexible sigmoidoscopy in an outpatient setting.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2007
Same author

Delayed diagnosis of rhabdomyoblastoma: a cautionary tale.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2007
Same author

Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow.

Theriogenology·2007
Same author

Babies behind bars; an Irish perspective.

Irish medical journal·2007
Same author

When a stroke is not a stroke; posterior leukoencephalopathy syndrome mimicking posterior circulation stroke.

Irish medical journal·2007

Area of Science:

  • Gynecology
  • Obstetrics
  • Public Health

Background:

  • Diethylstilbestrol (DES) is a synthetic estrogen previously prescribed to prevent miscarriage.
  • In utero DES exposure is linked to various gynecological abnormalities and increased cancer risk.
  • Establishing specialized clinics is crucial for monitoring and managing DES-exposed individuals.

Purpose of the Study:

  • To report the initial findings from a newly established Diethylstilbestrol (DES) clinic in Dublin.
  • To assess the prevalence of DES exposure and associated health issues in a cohort of women.
  • To document the early outcomes and clinical observations within the first six months of the clinic's operation.

Main Methods:

  • Retrospective analysis of patient inquiries and clinic visits over a six-month period.
  • Clinical examination, colposcopy, and review of medical histories to identify DES exposure and related abnormalities.
  • Categorization of women based on confirmed or possible in utero DES exposure.

Main Results:

  • 172 inquiries received, with 95 women attending the clinic.
  • 16 women confirmed and 8 possibly exposed to Diethylstilbestrol (DES) in utero.
  • 15 women displayed classical cervicovaginal signs; 6 reported pregnancy complications possibly linked to DES. No cervical intraepithelial neoplasia or vaginal clear-cell adenocarcinoma were found.

Conclusions:

  • The initial phase of the DES clinic identified a notable number of exposed women with varying clinical findings.
  • While significant abnormalities like cancer were not detected in this early cohort, the presence of classical signs and pregnancy issues warrants continued monitoring.
  • The clinic serves as a vital resource for managing the long-term health implications of Diethylstilbestrol (DES) exposure.

Related Experiment Videos