Related Experiment Video
Updated: Aug 14, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Multiple antigen concentrations in delayed-type hypersensitivity (DTH) and response diversity during and after
Jørgen Nyhus1, Anne-Marte Bakken Kran, Maja A Sommerfelt
1Bionor Immuno AS, P.O. Box. 1823, NO-3703 Skien, Norway. jorgen.nyhus@bionorimmuno.com
Abstract:
Delayed-type hypersensitivity (DTH) testing represents a simple in vivo method for monitoring cellular immune responses. In a phase II clinical trial on HIV-infected patients (n = 38) of the peptide-based HIV-1 immunotherapy candidate Vacc-4x, we monitored DTH responses to three antigen concentrations of Vacc-4x. We have shown that DTH can be used quantitatively to measure immune reactions to Vacc-4x and its individual peptide components. Our data stress the qualities and differences of induration and erythema, both in discriminating individual antigens and in monitoring immunizations over time. The data also indicate that DTH baseline-status might have important impact on immunization kinetics.
More Related Videos
Related Concept Videos
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
Vaccinations
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Cross-reactivity

