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Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Malignant extraovarian endometriosis: a review
Summary
Malignant transformation in endometriosis is rare, affecting up to 1% of women. Extra-ovarian endometriosis-associated cancers may require distinct therapeutic approaches compared to traditional ovarian cancers.
Area of Science:
- Gynecologic Oncology
- Reproductive Endocrinology
- Pathology
Background:
- Endometriosis is a condition where endometrial-like tissue grows outside the uterus.
- Malignant transformation of endometriosis is a rare but recognized complication.
- Extra-ovarian endometriosis accounts for a significant portion of these malignancies.
Purpose of the Study:
- To review the etiology and treatment of malignant transformation in extra-ovarian endometriosis.
- To highlight the distinct nature of endometriosis-associated cancers.
Main Methods:
- Literature search of MEDLINE database for English language studies.
- Extensive review of bibliographies from identified articles.
Main Results:
- Up to 1% of women with endometriosis develop neoplasm.
- Nearly 25% of endometriosis-associated malignancies occur in extra-ovarian tissues.
- Hormonal factors (e.g., estrogen monotherapy in obese patients) and genetic anomalies (e.g., chromosome 5q loss of heterozygosity) are implicated in pathogenesis.
- Survival rates vary significantly: 82-100% 5-year survival for localized endometrioid type, versus 0-12% for disseminated intraperitoneal disease.
Conclusions:
- Endometriosis-associated cancers may represent a distinct patient class.
- Therapeutic strategies for these cancers may differ from those for traditional ovarian cancers.
