Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual differences in extraversion and dopamine genetics predict neural reward responses.

Michael X Cohen1, Jennifer Young, Jong-Min Baek

  • 1Department of Epileptology, University of Bonn, 53115 Bonn, Germany; Center for Neuroscience, University of California, Davis, CA 95616, USA. mcohen@ucdavis.edu

Brain Research. Cognitive Brain Research
|November 18, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A methotrexate dashboard: integrating MTXPK.org into the electronic health record to facilitate model-informed care for pediatric patients receiving high-dose methotrexate.

JAMIA open·2026
Same author

Management of acute dental pain in adults.

Canadian family physician Medecin de famille canadien·2026
Same author

Canadian family physician Medecin de famille canadien·2026
Same author

Acetylsalicylic acid use for artial fibrillation and bleeding risk.

Canadian family physician Medecin de famille canadien·2026
Same author

Natural language processing captures memory content associated with shared neural patterns at encoding and retrieval.

Communications psychology·2026
Same author

Fatal Human Case of Highly Pathogenic Avian Influenza A(H5N5) in a Backyard Flock Owner - Washington, November 2025.

MMWR. Morbidity and mortality weekly report·2026

Individual differences in extraversion and the dopamine D2 receptor gene influence brain reward system activity during gambling. This research links personality, genetics, and brain function in reward processing.

Area of Science:

  • Neuroscience
  • Behavioral Genetics
  • Psychology

Background:

  • Extraversion is linked to reward sensitivity and dopamine function.
  • The neural mechanisms underlying these links in the brain's reward system are not well understood.

Purpose of the Study:

  • To investigate how extraversion and dopamine D2 receptor gene (DRD2) Taq1A polymorphism relate to brain reward system activation.
  • To examine these relationships during a gambling task using functional magnetic resonance imaging (fMRI).

Main Methods:

  • Two fMRI experiments were conducted with participants performing a gambling task.
  • Participants received probabilistic rewards either immediately or after an anticipation period.
  • Individual differences in extraversion and the presence of the DRD2 Taq1A allele were assessed.

Related Experiment Videos

Main Results:

  • Group analyses showed reward- and anticipation-related activations in the brain's reward system.
  • Individual differences in extraversion and the DRD2 Taq1A allele significantly predicted variability in reward-related activation magnitudes.
  • These genetic and personality factors did not predict anticipation-related activation variability.

Conclusions:

  • Stable individual differences in personality (extraversion) and genetics (DRD2 Taq1A allele) are associated with brain reward system functioning.
  • These findings highlight a neurobiological basis for the interplay between personality, genetics, and reward processing.