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Updated: Aug 14, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents
Fernando D Suvire1, Maximiliano Sortino, Vladimir V Kouznetsov
1Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (U.N.S.L.), Chacabuco 917, 5700 San Luis, Argentina.
Abstract:
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
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