Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Microfluidic technology for PET radiochemistry.

J M Gillies¹, C Prenant, G N Chimon

¹Cancer Research-UK/University of Manchester Radiochemical Targeting and Imaging Group, Paterson Institute for Cancer Research, Manchester M20 4BX, UK. jgillies@picr.man.ac.uk

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine

|November 18, 2005

Summary

Microfluidic technology enables rapid synthesis of radiopharmaceuticals for positron emission tomography (PET) imaging. This approach significantly reduces reaction times for producing tracers like fluorodeoxyglucose (FDG) and Annexin-V.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Encapsulation of <sup>67</sup>Cu therapeutic radiometal in luminescent lanthanide phosphate core and core-shell nanoparticles.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2022

Same author

A review of approaches to <sup>18</sup> F radiolabelling affinity peptides and proteins.

Journal of labelled compounds & radiopharmaceuticals·2018

Same author

Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2017

Same author

In vivo characterisation of a therapeutically relevant self-assembling <sup>18</sup> F-labelled β-sheet forming peptide and its hydrogel using positron emission tomography.

Journal of labelled compounds & radiopharmaceuticals·2017

Same author

SU-D-217A-04: Evaluation of the Spatial Concordance Between the Intratumoral Patterns of 18F-FLT and 18F-FDG Uptake in a Small Animal Tumor Model.

Medical physics·2017

Same author

Mechanistic Studies on the Self-Assembly of PLGA Patchy Particles and Their Potential Applications in Biomedical Imaging.

Langmuir : the ACS journal of surfaces and colloids·2016

Area of Science:

Radiochemistry
Nuclear Medicine
Microfluidics

Background:

Positron emission tomography (PET) relies on radiopharmaceuticals for imaging.
Traditional radiopharmaceutical synthesis can be time-consuming.
Microfabrication offers potential for improved reaction efficiency.

Purpose of the Study:

To demonstrate the first application of microfluidic systems in PET radiochemistry.
To synthesize PET radiopharmaceuticals using fluorine-18 and iodine-124 labels.
To evaluate the efficiency and speed of microfluidic synthesis compared to conventional methods.

Main Methods:

Utilized microfluidic technology for radiochemical reactions.
Synthesized [(18)F]FDG via nucleophilic substitution.

Related Experiment Videos

Synthesized (124)I Annexin-V via direct iodination.

Employed established radiolabeling techniques within a microfabricated system.

Main Results:

Achieved 50% incorporation of F-18 radioactivity for [(18)F]FDG in 4 seconds.
Obtained 40% radiolabeling efficiency for (124)I Annexin-V in 1 minute.
Demonstrated comparable yields to conventional methods but with significantly reduced reaction times.
Validated the use of microfluidics for both low and high molecular weight compounds.

Conclusions:

Microfluidic systems offer a viable platform for rapid radiopharmaceutical synthesis.
This technology has the potential to simplify and accelerate the production of PET tracers.
Further optimization of microfluidic devices can lead to improved yields and efficiency for short and medium half-life radionuclides.