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Lung function in type 2 diabetes: the Normative Aging Study.

Augusto A Litonjua1, Ross Lazarus, David Sparrow

  • 1Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. augusto.litonjua@channing.harvard.edu

Respiratory Medicine
|November 18, 2005
PubMed
Summary
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Men predisposed to diabetes show reduced lung function years before diagnosis, with this decline persisting after diabetes onset. This suggests insulin resistance impacts lung health.

Area of Science:

  • Pulmonary Medicine
  • Endocrinology
  • Aging Research

Background:

  • Cross-sectional studies indicate lower lung function in individuals with diabetes.
  • This study investigates longitudinal changes in lung function related to diabetes development.

Purpose of the Study:

  • To determine if diabetic subjects exhibit different rates of lung function decline compared to non-diabetic subjects.
  • To analyze lung function changes in relation to diabetes development over time.

Main Methods:

  • A nested case-control analysis was performed on 352 men who developed diabetes and 352 controls.
  • Lung function, including forced expiratory volume in 1s (FEV1) and forced vital capacity (FVC), was assessed at three time points: pre-diagnosis, diagnosis, and follow-up.

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Main Results:

  • Diabetic subjects demonstrated lower FEV1 and FVC at all assessed time points, even after adjusting for covariates.
  • No significant differences in the rates of FEV1 or FVC change over time were observed between diabetic and non-diabetic groups.

Conclusions:

  • Decreased lung function is evident in men predisposed to diabetes years before clinical diagnosis.
  • This lung function decrement persists post-diabetes diagnosis, suggesting a link to insulin resistance mechanisms.