Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Animal models for spinal fusion.

Inneke H Drespe1, Gert K Polzhofer, A Simon Turner

  • 1Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, PO Box 208071, New Haven, CT 06520-8071, USA.

The Spine Journal : Official Journal of the North American Spine Society
|November 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes following total shoulder arthroplasty in patients with systemic lupus erythematosus.

Journal of shoulder and elbow surgery·2024
Same author

Risk Factors for Perioperative Nerve Injury Related to Total Hip Arthroplasty.

Arthroplasty today·2024
Same author

Utilization and timing of surgical intervention for central cord syndrome in the United States.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2024
Same author

Emergency department utilization after elbow arthroscopy.

JSES international·2024
Same author

A Nationwide Analysis of Complications, Reoperations, and Cost of Wide-Awake Flexor Tendon Repairs.

Plastic and reconstructive surgery·2024
Same author

The Association of Surgical Setting With Opioid Prescribing Patterns Following Wide-Awake Trigger Finger Release.

Annals of plastic surgery·2024
Same journal

Clinical and Radiological Characteristics Associated With Revision Anterior Surgery After Initial Posterior Decompression for Cervical Ossification of the Posterior Longitudinal Ligament: A Time-to-Event Analysis.

The spine journal : official journal of the North American Spine Society·2026
Same journal

3D-Printed Porous Titanium versus Polyetheretherketone Cages in Lumbar Interbody Fusion: A Prospective, Multicenter, Randomized Controlled Trial with Bone Mineral Density Stratification.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Quantifying Postural Recovery After Lumbar Decompression: Cone of Economy Biomarkers of Balance Effort and Stability in Patients with Radiculopathy and Neurogenic Claudication.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Malnutrition and Adverse Outcomes after Spine Surgery: A Systematic Review and Meta-Analysis.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Diagnostic Value of Upright-Supine Imaging and Its Association with Postoperative Outcomes in Degenerative Lumbar Spondylolisthesis - A Two-Year PROM Based Comparison with Flexion Extension Radiographs.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Clinical Significance of Early MRI Assessment Following Separation Surgery for Metastatic Spinal Cord Compression.

The spine journal : official journal of the North American Spine Society·2026
See all related articles

Animal models are crucial for testing spinal fusion techniques and bone grafts before human trials. These models help quantify results and establish the "burden of proof" for new methods.

Area of Science:

  • Orthopedics
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Animal models are vital for preclinical evaluation of spinal fusion.
  • They enable controlled variable assessment and outcome measurement.
  • The progression from small to large animal models follows a
  • burden of proof
  • cascade.

Purpose of the Study:

  • To review animal models used in spinal fusion research.
  • To discuss methods for analyzing fusion outcomes.
  • To provide a framework for interpreting bone graft studies.

Main Methods:

  • Review of established animal models for spinal fusion.
  • Analysis of fusion assessment techniques (radiography, CT, histology, biomechanics).

Related Experiment Videos

  • Consideration of variables influencing bone graft efficacy.

    • Main Results:

    • Various animal models exist for spinal fusion research.
    • Multiple analytical methods provide comprehensive fusion assessment.
    • Understanding model characteristics and variables is key for bone graft evaluation.

    Conclusions:

    • Animal models are indispensable for advancing spinal fusion technologies.
    • Standardized evaluation methods enhance the reliability of preclinical data.
    • Accumulated evidence from animal studies guides clinical trial development.