Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell technologies for spinal fusion.

Francis H Shen1, Dino Samartzis, Howard S An

  • 1Department of Orthopaedic Surgery, University of Virginia Health System, PO Box 800159, Charlottesville, VA 22908, USA. fhs2g@virginia.edu

The Spine Journal : Official Journal of the North American Spine Society
|November 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ISSLS Prize in Bioengineering Science 2026: Hidden in Plain Sight: Machine Learning-Assisted MRI Reveals Novel Vertebral Body Biomarkers of Chronic Low Back Pain in Humans.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Celebrating ISSLS Science, Leadership, Legacy, and Partnership with the European Spine Journal.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Chronic Back Pain Increases Alzheimer's Disease Risk Independent of Gross Brain Structural Alterations: Genetic Evidence from Two Populations.

Journal of pain research·2026
Same author

False references, real consequences: safeguarding spine evidence.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Bringing temporomandibular joint disorders and implant replacement into musculoskeletal medicine: The need for robust research, regulation and patient safety.

Cranio : the journal of craniomandibular practice·2026
Same author

Editorial responsibility and peer review in the age of artificial intelligence.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same journal

Clinical and Radiological Characteristics Associated With Revision Anterior Surgery After Initial Posterior Decompression for Cervical Ossification of the Posterior Longitudinal Ligament: A Time-to-Event Analysis.

The spine journal : official journal of the North American Spine Society·2026
Same journal

3D-Printed Porous Titanium versus Polyetheretherketone Cages in Lumbar Interbody Fusion: A Prospective, Multicenter, Randomized Controlled Trial with Bone Mineral Density Stratification.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Quantifying Postural Recovery After Lumbar Decompression: Cone of Economy Biomarkers of Balance Effort and Stability in Patients with Radiculopathy and Neurogenic Claudication.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Malnutrition and Adverse Outcomes after Spine Surgery: A Systematic Review and Meta-Analysis.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Diagnostic Value of Upright-Supine Imaging and Its Association with Postoperative Outcomes in Degenerative Lumbar Spondylolisthesis - A Two-Year PROM Based Comparison with Flexion Extension Radiographs.

The spine journal : official journal of the North American Spine Society·2026
Same journal

Clinical Significance of Early MRI Assessment Following Separation Surgery for Metastatic Spinal Cord Compression.

The spine journal : official journal of the North American Spine Society·2026
See all related articles

Successful spinal fusion requires bone-forming cells (osteoblasts) or mesenchymal stem cells (MSCs), biological signals, and a scaffold. Current research focuses on optimizing MSCs for bone regeneration, improving spinal fusion success.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopedic Surgery

Background:

  • Spinal fusion success hinges on osteoblasts, biological signals, and scaffolds.
  • Mesenchymal stem cells (MSCs) are crucial bone-forming precursors.
  • Current techniques aim to enhance MSCs for improved spinal fusion outcomes.

Purpose of the Study:

  • To review the essential components for successful spinal fusion.
  • To explore the role and optimization of mesenchymal stem cells (MSCs) in bone regeneration.
  • To discuss current and future cellular technologies for spinal fusion.

Main Methods:

  • Literature review of terminology and historical context.
  • Analysis of current research on MSC harvesting and delivery.

Related Experiment Videos

  • Discussion of existing and emerging cellular technologies.

    • Main Results:

    • Mesenchymal stem cells (MSCs) are the most critical element for spinal fusion.
    • Optimizing MSCs involves improving their harvest, concentration, delivery, and action.
    • Various cellular technologies are being developed to enhance MSC efficacy.

    Conclusions:

    • Mesenchymal stem cells (MSCs) are pivotal for spinal fusion.
    • Advancements in cellular technologies are key to overcoming spinal fusion challenges.
    • Future research will likely focus on refining MSC-based therapies for bone regeneration.