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Updated: Aug 14, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Dental avulsions and blood coagulation disorders]
E Szekely1, M-M Baralle, G Raoul
1Service de Stomatologie et Chirurgie Maxillo-Faciale, Hôpital Roger Salengro, bd du Pr J. Leclercq, 59037 Lille Cedex.
Introduction:
We performed a retrospective study of tooth removal for patients with coagulation disorders.
Material And Method:
The study included 67 patients divided into 3 groups according to their coagulation disorder. The first group included 31 patients with a congenital disorder, the second 19 patients receiving anticoagulant therapy, and the third 16 patients with an acquired disorder. The same surgical procedure was used for all patients: alveoli regulation, socket preparation with resorbable oxycellulose dressing, and sutures with separate stitches. Biological glue and celluloid splints were not used. Depending on the severity of the coagulation disorder, factor VIII or concentrated von Willebrand factor or Desmopressine was administered for patients in the first group. If possible, low-molecular-weight heparin replaced oral anticoagulation for patients in the second group. Platelet concentrates were administered for 2 of the patients in the third group.
Results:
Postoperative bleeding was noted in 4 patients in the first group, 2 in the second and 2 in the third.
Discussion:
We have abandoned the use of biological glue and celluloid splints. The rate of bleeding in the first and second group was similar to that reported in the literature. We were unable to find any comparable report for the third group.
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