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Updated: Aug 14, 2026

Three-Dimensional Phase Resolved Functional Lung Magnetic Resonance Imaging
Published on: June 21, 2024
Correlation between HRCT and pulmonary functional tests in cystic fibrosis
Paola Mastellari1, Simona Biggi, Alfonsa Lombardi
1Dipartimento di Scienze Cliniche, Università degli Studi di Parma, Parma, Italy. paolamast@libero.it
Purpose:
To compare the HRCT score by Oikonomou and air trapping in expiratory scans with pulmonary functional tests and evaluate which radiological criteria are more useful to predict clinical impairment.
Materials And Methods:
From January to September 2003, pulmonary HRCT study was performed in 37 patients (23 males), aged between 7 and 41 years, with cystic fibrosis. In the same day of CT examination they also received a complete functional evaluation. HRCT studies were evaluated by three radiologists blinded to the clinical data and were correlated with the lung function tests.
Results:
We obtained a high correlation (p=0.01) for two of the HRCT signs: extent of mucus plugging and mosaic perfusion pattern and all function tests.
Discussion:
Previous studies have demonstrated good correlation between lung function tests, in particular with FEV1,and HRCT signs. Our study differed from previous ones in that we analysed the correlation between lung function tests and with both single and combined CT criteria.
Conclusions:
Our results suggest that a simplified HRCT score could be useful to evaluate patients with cystic fibrosis.
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