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Related Experiment Videos

Cryofibrinogenemia associated with polyarteritis nodosa.

Junsuke Shimbo1, Atsuo Miwa, Kenju Aoki

  • 1Neurology, Toyama Prefectural Central Hospital, Toyama, Japan. shimbo@bri.niigata-u.ac.jp

Clinical Rheumatology
|November 18, 2005
PubMed
Summary

This study details a rare case of polyarteritis nodosa (PAN) linked with cryofibrinogenemia, presenting with cold-induced symptoms. Treatment with corticosteroids effectively managed both PAN and cryofibrinogenemia.

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Area of Science:

  • Rheumatology
  • Immunology
  • Vascular Medicine

Background:

  • Polyarteritis nodosa (PAN) is a systemic vasculitis affecting medium-sized arteries.
  • Cryofibrinogenemia is a condition characterized by the presence of cryofibrinogens in the blood.
  • The association between PAN and cryofibrinogenemia has not been previously reported.

Observation:

  • A 77-year-old woman presented with polyarthralgia and digital gangrene triggered by cold exposure.
  • Biopsy confirmed the diagnosis of polyarteritis nodosa.
  • Laboratory markers, including cryofibrinogen levels, were monitored.

Findings:

  • The patient's clinical manifestations and laboratory parameters, including cryofibrinogen, showed a positive response to corticosteroid therapy.
  • This case represents the first reported instance of the co-occurrence of PAN and cryofibrinogenemia.

Related Experiment Videos

  • Cryofibrinogenemia may be associated with polyarteritis nodosa.

    • Implications:

    • This finding suggests a potential link between cryofibrinogenemia and PAN.
    • Screening for cryofibrinogen is recommended in PAN patients experiencing cold-induced symptoms.
    • Further research is warranted to elucidate the pathogenetic mechanisms underlying this association.