Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial protection in reperfusion with postconditioning.

Jakob Vinten-Johansen1, Zhi-Qing Zhao, Rong Jiang

  • 1Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, Emory Crawford Long Hospital, Atlanta, GA 30308-2225, USA. jvinten@emory.edu

Expert Review of Cardiovascular Therapy
|November 19, 2005
PubMed
Summary

Postconditioning, a method involving brief cycles of blood flow restoration and blockage, effectively reduces heart damage after reperfusion. This technique shows promise for widespread clinical use in cardiac procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary: Methods are the investigator's lens.

JTCVS techniques·2021
Same author

CQMUH-011 mitigates autoimmune hepatitis via inhibiting the function of T lymphocytes.

Drug development research·2021
Same author

The predictive value of minute ventilation versus carbon dioxide production in pulmonary hypertension associated with left heart disease.

Annals of translational medicine·2021
Same author

Methylation of ERβ 5'-untranslated region attenuates its inhibitory effect on ERα gene transcription and promotes the initiation and progression of papillary thyroid cancer.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2021
Same author

Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial.

The Lancet. Oncology·2021
Same author

Impact of circGSAP in Peripheral Blood Mononuclear Cells on Idiopathic Pulmonary Arterial Hypertension.

American journal of respiratory and critical care medicine·2021

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Cellular Biology

Background:

  • Reperfusion is crucial for treating coronary occlusive disease but can cause significant reperfusion injury.
  • Reperfusion injury exacerbates post-ischemic damage, including endothelial dysfunction, infarction, and apoptosis.
  • Early reperfusion events dictate the severity of myocardial damage.

Purpose of the Study:

  • To investigate the cardioprotective effects of postconditioning, a novel reperfusion strategy.
  • To compare the efficacy of postconditioning with established methods like ischemic preconditioning.
  • To elucidate the mechanisms underlying postconditioning-induced cardioprotection.

Main Methods:

  • Application of brief, iterative episodes of reflow (reoxygenation) and reocclusion (ischemia) at the onset of reperfusion.

Related Experiment Videos

  • Evaluation of infarct size, apoptosis, endothelial injury, and arrhythmias in various animal and cell models.
  • Analysis of signaling pathways and molecular effectors involved in cardioprotection.

    • Main Results:

    • Postconditioning significantly reduced infarct size, apoptosis, endothelial injury, and reperfusion arrhythmias.
    • Cardioprotection achieved by postconditioning was comparable to ischemic preconditioning.
    • Mechanisms involve reduced oxidant burden, attenuated inflammation, and activation of survival kinases.

    Conclusions:

    • Postconditioning is a potent cardioprotective strategy effective during reperfusion.
    • It mitigates key manifestations of reperfusion injury through multiple molecular pathways.
    • Its applicability during reperfusion offers broad clinical potential for angioplasty, surgery, and transplantation.