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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
Published on: April 6, 2017
Aerosol delivery devices and obstructive airway disease
1Division of Pulmonary and Critical Care Medicine, SUNY at Stony Brook, HSC-17-040, Stony Brook, NY 11794-8172, USA. toriordan@notes.cc.sunysb.edu
Abstract:
Two obstructive lung diseases, asthma and chronic obstructive pulmonary disease, account for the vast majority of prescriptions for aerosolized medications and devices . Asthma is an immunologically mediated condition characterized by episodic reversible airway obstructions that occur in all age groups. In contrast, chronic obstructive pulmonary disease is a condition characterized by relatively irreversible obstruction that is seen in middle-aged and elderly cigarette smokers. Nevertheless, there is sufficient overlap in terms of airway physiology and therapeutics to allow a review of the challenge of aerosol delivery in both conditions in the same article. This review will concentrate on issues related to aerosol delivery.
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