Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stimuli-responsive polymers in gene delivery.

Erhan Piskin1

  • 1Hacettepe University, Chemical Engineering Department, Bioengineering Division, Beytepe, Ankara, Turkey. piskin@hacettepe.edu.tr

Expert Review of Medical Devices
|November 19, 2005
PubMed
Summary

Novel stimuli-responsive polymers offer enhanced gene delivery for clinical therapies. These advanced vectors improve gene expression efficiency and selectivity, overcoming limitations of viral and traditional nonviral methods for treating diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Alginate- and Chitosan-Modified Gelatin Hydrogel Microbeads for Delivery of <i>E. coli</i> Phages.

Gels (Basel, Switzerland)·2024
Same author

The Pimpled Gold Nanosphere: A Superior Candidate for Plasmonic Photothermal Therapy.

International journal of nanomedicine·2020
Same author

Following hybridization on sensor/array platforms by using SPR, elipsometer and MALDI-MS.

Nucleosides, nucleotides & nucleic acids·2020
Same author

<i>In vivo</i> imaging/detection of MRSA bacterial infections in mice using fluorescence labelled polymeric nanoparticles carrying vancomycin as the targeting agent.

Journal of biomaterials science. Polymer edition·2019
Same author

Stem cells combined 3D electrospun nanofibrous and macrochannelled matrices: a preliminary approach in repair of rat cranial bones.

Artificial cells, nanomedicine, and biotechnology·2019
Same author

Critical-size alveolar defect treatment via TGF-ß3 and BMP-2 releasing hybrid constructs.

Journal of biomaterials science. Polymer edition·2019

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • Gene therapy utilizes nucleic acids (DNA, RNA, oligonucleotides) to modify gene expression for disease treatment.
  • Gene delivery relies on vectors, with viral vectors showing high efficiency but significant side effects.
  • Nonviral vectors, primarily cationic polymers, are used but often exhibit low transfection rates.

Purpose of the Study:

  • To explore stimuli-responsive polymers as novel vectors for gene delivery.
  • To achieve high gene expression efficiency and selective gene expression in therapeutic applications.

Main Methods:

  • Investigated the use of stimuli-responsive polymers as gene delivery vectors.
  • Compared the performance of these novel vectors against traditional viral and nonviral systems.

Related Experiment Videos

Main Results:

  • Stimuli-responsive polymers demonstrated high gene expression efficiency.
  • These novel vectors provided more selective gene expression compared to existing methods.

Conclusions:

  • Stimuli-responsive polymers represent a promising advancement in gene delivery technology.
  • These vectors offer a dual benefit of enhanced efficiency and selectivity for therapeutic gene delivery.