Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Strength at the extracellular matrix-muscle interface.

M D Grounds1, L Sorokin, J White

  • 1School of Anatomy and Human Biology, The University of Western Australia, Perth, WA, Australia. mgrounds@anhb.uwa.edu.au

Scandinavian Journal of Medicine & Science in Sports
|November 19, 2005
PubMed
Summary

Skeletal muscle force transfer relies on connections between sarcomeres, the cell membrane, and connective tissue. Disruptions to this system impair muscle strength and can cause severe muscle diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Buprenorphine for the management of opioid withdrawal.

The Cochrane database of systematic reviews·2000
Same author

Testing the association between residential fungus and health using ergosterol measures and cough recordings.

Mycopathologia·2000
Same author

Midwifery, politics and survival.

Australian College of Midwives Incorporated journal·2000
Same author

Nitric oxide modulation of TNF-alpha-induced cardiac contractile dysfunction is concentration dependent.

American journal of physiology. Heart and circulatory physiology·2000
Same author

Caregiver quality of life after autologous bone marrow transplantation.

Cancer nursing·2000
Same author

Cancer clinical trials and subject use of natural herbal products.

Cancer investigation·2000

Area of Science:

  • Biomechanical Engineering
  • Cell Biology
  • Muscle Physiology

Background:

  • Skeletal muscle generates force via myofibrillar protein contraction.
  • Force transmission from sarcomeres to bones involves complex cellular and extracellular components.

Purpose of the Study:

  • To explore the mechanism of contractile force transfer from sarcomeres through connective tissue to bones.
  • To evaluate the linkages between basement membrane molecules, sarcolemma, cytoskeleton, and sarcomeres.

Main Methods:

  • Review of mechanical force transfer pathways in skeletal muscle.
  • Analysis of molecular connections between extracellular matrix and intracellular structures.
  • Discussion of defects in laminin-alpha2 and integrin-alpha7.

Related Experiment Videos

Main Results:

  • Force transfer initiates at the sarcolemma, moving to the basement membrane and then connective tissue.
  • Integrity of connections between extracellular and intracellular components is crucial for muscle strength.
  • Defects in specific molecules like laminin-alpha2 and integrin-alpha7 compromise muscle function.

Conclusions:

  • The mechanical integrity of the muscle fiber system is vital for skeletal muscle strength and health.
  • Understanding these linkages offers potential for novel interventions against muscle diseases and aging.
  • Targeting these connections may enhance muscle strength and reduce damage.