Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression.

Chad A Corcoran1, Xiuquan Luo, Qin He

  • 1Department of Pharmacology, State University of New York, Upstate Medical, Syracuse, New York 13210, USA.

Cancer Biology & Therapy
|November 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell Death, Molecular Targeted Therapies, and Metabolic Reprogramming in EGFR-Mutant Lung Cancer.

Cancers·2025
Same author

High Glucose and Glucose-derived Intermediates are Linked to Lung Cancer Aggressiveness.

Current cancer drug targets·2025
Same author

Metabolic stress-mediated cell death and autophagy in human lung cancer cells.

The Journal of pharmacology and experimental therapeutics·2025
Same author

ECRG2/SPINK7 Tumor Suppressor as Modulator of DNA Damage Response.

International journal of molecular sciences·2024
Same author

A Delphi Study to Construct an Index of Practice for Community Nurses Providing Transitional Home Care for Patients with Chronic Diseases.

Inquiry : a journal of medical care organization, provision and financing·2024
Same author

The oncogenic potential of Rab-like protein 1A (RBEL1A) GTPase: The first review of RBEL1A research with future research directions and challenges.

Journal of Cancer·2023

The gene TRB3 is upregulated by endoplasmic reticulum (ER) stress but downregulated by genotoxic stress, revealing stress-specific signaling roles. This highlights TRB3

Area of Science:

  • Cellular stress response
  • Molecular biology
  • Signaling pathways

Background:

  • The protein TRB3 is implicated in apoptosis and modulation of the Akt/PKB signaling pathway.
  • Cellular stress responses involve complex signaling cascades that dictate cell fate.

Purpose of the Study:

  • To investigate the differential regulation of TRB3 expression under various cellular stress conditions.
  • To elucidate the role of TRB3 in distinct stress-response pathways.

Main Methods:

  • Treatment of cells with endoplasmic reticulum (ER) stress-inducing agents (calcium depletion, protein trafficking disruption).
  • Treatment of cells with genotoxic stress-inducing agents (DNA damage).
  • Quantitative analysis of TRB3 gene expression levels.
  • Investigation of p53-dependent and -independent mechanisms.

Related Experiment Videos

Main Results:

  • Endoplasmic reticulum (ER) stress significantly upregulates TRB3 expression.
  • Genotoxic stress significantly downregulates TRB3 expression via p53-dependent and -independent pathways.
  • TRB3 is identified as the first gene exhibiting opposing expression patterns in response to ER stress and genotoxic stress.

Conclusions:

  • TRB3 expression is tightly regulated in a stress-specific manner.
  • The findings underscore the existence of distinct signaling cascades for different types of cellular stress.
  • TRB3 plays a complex and potentially divergent role in cellular stress responses.