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Periportal high intensity on T2-weighted MR images in acute viral hepatitis
1Department of Radiology, Matsunami General Hospital, Gifu, Japan.
Abstract:
The frequency and degree of periportal high intensity (PHI) on T2-weighted images in 28 patients (32 MR studies) with acute viral hepatitis were analyzed with regard to the various levels of serum glutamic-oxaloacetic transaminase (SGOT) and clinical phases. Periportal high intensity was found in 16 of 32 MR studies (50%) and no definite PHI was found in 7 studies (22%). Periportal high intensity appeared when the SGOT level was greater than 500 IU or when the phase of the disease was early. Follow-up studies revealed that PHI decreased during clinical recovery. We conclude that the degree of PHI on T2-weighted images reflects the severity of the disease in acute viral hepatitis.
Insights
Periportal high intensity (PHI) on T2-weighted MRI scans indicates the severity of acute viral hepatitis. This finding is more common in early disease stages with high serum glutamic-oxaloacetic transaminase (SGOT) levels.
Area of Science:
- Radiology
- Hepatology
- Medical Imaging
Background:
- Acute viral hepatitis is a significant liver inflammation.
- Accurate assessment of disease severity is crucial for patient management.
Purpose of the Study:
- To investigate the correlation between periportal high intensity (PHI) on T2-weighted MRI and disease severity in acute viral hepatitis.
- To assess the relationship between PHI, serum glutamic-oxaloacetic transaminase (SGOT) levels, and clinical phases.
Main Methods:
- Retrospective analysis of 32 MRI studies from 28 patients with acute viral hepatitis.
- Evaluation of T2-weighted images for periportal high intensity (PHI).
- Correlation of PHI findings with SGOT levels and clinical disease stages.
Main Results:
- Periportal high intensity (PHI) was observed in 50% of the MR studies.
- PHI was significantly associated with SGOT levels exceeding 500 IU/L.
- PHI was more prevalent in the early stages of acute viral hepatitis.
- Follow-up studies showed a decrease in PHI during clinical recovery.
Conclusions:
- The degree of periportal high intensity (PHI) on T2-weighted MRI is a valuable indicator of disease severity in acute viral hepatitis.
- PHI can aid in assessing the inflammatory activity and progression of acute viral hepatitis.