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Related Concept Videos

Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

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An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
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Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Related Experiment Video

Updated: Mar 24, 2026

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets
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Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets

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[Coupling between adherent leukocytes and blood flow].

Xiaoheng Liu1, Hua Huang, Huaiqing Chen

  • 1Laboratory of Cardiovascular Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|November 22, 2005
PubMed
Summary
This summary is machine-generated.

This study models leukocyte-blood flow interactions, finding that blood flow alters shear stress distribution on adhered cells. Non-uniform shear stress may impact leukocyte shape and function.

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A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
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Related Experiment Videos

Last Updated: Mar 24, 2026

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets
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Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
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A Flow Adhesion Assay to Study Leucocyte Recruitment to Human Hepatic Sinusoidal Endothelium Under Conditions of Shear Stress
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Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Cellular Biology

Context:

  • Understanding leukocyte adhesion and behavior is crucial in inflammatory diseases.
  • Blood flow dynamics significantly influence cellular interactions at vessel walls.

Purpose:

  • To develop a theoretical model simulating leukocyte-blood flow coupling.
  • To analyze shear stress and pressure distributions on adhered leukocytes using computational fluid dynamics (CFD).

Summary:

  • A CFD model coupled with laser Doppler velocimetry measurements revealed that leukocyte deformation increases with initial contact angle and Reynolds number.
  • Blood flow causes shear stress and pressure redistribution on the cell surface, with maximum shear stress occurring at the cell's apex.

Impact:

  • The non-uniform shear stress distribution suggests a key role in altering leukocyte shape and function.
  • This research provides insights into the biomechanics of leukocyte adhesion and potential therapeutic targets.