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Updated: Aug 14, 2026

A Colorimetric Assay that Specifically Measures Granzyme B Proteolytic Activity: Hydrolysis of Boc-Ala-Ala-Asp-S-Bzl
Published on: November 28, 2014
[Perforin and granzyme--the perfect material of biologic missile]
Hongmei Dong1, Xiaohu Xu, Xiaojun Yu
1Department of Forensic Medicine, Medical College of Shantou University, Shantou 515041, China. hmdong@stu.edu.cn
Abstract:
Perforin and granzyme are important effector molecules in cytolytic cells. They can induce apoptosis of tumor cells and infection cells. The research of biologic missile is noticed with the progress in therapy targeting to the disease. It is supposed that perforin and granzyme play an important role in biological missiles because of their biologic function and structure. A review on several aspects of these effector molecules is presented.
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