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Updated: Aug 13, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Structure-activity relationships of dengue antiviral polycyclic quinones
Dominique Laurent1, Francine Baumann, Anne Gaelle Benoit
1Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, UMR152 IRD - Université Paul Sabatier, Centre IRD, Nouméa, Nouvelle-Calédonie, France.
Abstract:
The virucidal and antiviral photoactivities of three compounds, hypericin, tetrabromohypericin and gymnochrome B, were evaluated against dengue viruses. All the three products were active, and both the virucidal and antiviral activities were enhanced by light. Gymnochrome B was more potent than hypericin and tetrabromohypericin. The presence of the side chains on the hypericin core of gymnochromes appears to be beneficial for both virucidal and antiviral activities. This enhanced activity is likely to be linked to a complementary mechanism independent of photoactivation.
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