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Enrichment and Detection of Clostridium perfringens Toxinotypes in Retail Food Samples
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Antimicrobial resistance among Clostridium perfringens isolated from various sources in Thailand

Unchalee Tansuphasiri1, Wiriya Matra, Leelaowadee Sangsuk

  • 1Department of Microbiology, Faculty of Public Health, Mahidol University, Bangkok; Thailand. unchalee@loxley.co.th

The Southeast Asian Journal of Tropical Medicine and Public Health
|November 22, 2005
PubMed

Insights

Clostridium perfringens exhibits significant antimicrobial resistance, particularly to tetracycline. Many strains, especially from human feces, display multiple-drug resistance, posing a public health concern.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance
  • Food Safety

Background:

  • Clostridium perfringens is an opportunistic pathogen found in various environments.
  • Antimicrobial resistance in C. perfringens is a growing concern for human and animal health.

Purpose of the Study:

  • To assess antimicrobial resistance patterns of Clostridium perfringens.
  • To identify resistance prevalence in strains from human, animal, food, and environmental sources.

Main Methods:

  • Tested 201 PCR-confirmed C. perfringens strains for resistance to 7 antimicrobial agents.
  • Determined minimal inhibitory concentrations (MICs) using the agar dilution method.

Main Results:

  • Highest resistance observed for tetracycline (56.2%), imipenem (24.9%), and metronidazole (9.5%).
  • Tetracycline resistance was prevalent across all sources, especially pig feces (77.8%).
  • 39.3% of resistant strains showed single-drug resistance, while 23.4% were multiple-drug resistant (MDR).

Conclusions:

  • Clostridium perfringens demonstrates high resistance to tetracycline and varying levels to other antimicrobials.
  • Multiple-drug resistant strains, predominantly from human feces, highlight the need for monitoring and control strategies.

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