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Multiple cerebral abscesses complicating hepatopulmonary amebiasis.

F B Hughes, S T Faehnle, J L Simon

    The Journal of Pediatrics
    |January 1, 1975
    PubMed
    Summary
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    A child with liver and lung amebiasis developed brain abscesses. Prolonged treatment with metronidazole and chloroquine phosphate, alongside brain scans, led to improvement, suggesting this approach for cerebral amebiasis.

    Area of Science:

    • Infectious Diseases
    • Neurology
    • Hepatology

    Background:

    • Hepatopulmonary amebiasis is a severe manifestation of Entamoeba histolytica infection.
    • Cerebral amebiasis is a rare but life-threatening complication.
    • Early recognition and treatment are crucial for patient outcomes.

    Purpose of the Study:

    • To report a case of hepatopulmonary amebiasis complicated by cerebral abscesses.
    • To evaluate the efficacy of prolonged combined therapy for cerebral amebiasis.
    • To emphasize the importance of considering cerebral involvement in amebiasis.

    Main Methods:

    • Case report of a 3-year-old boy with confirmed hepatopulmonary amebiasis.
    • Initial treatment with chloroquine phosphate followed by the development of brain abscesses.

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  • Subsequent prolonged combined therapy with metronidazole and chloroquine phosphate.
  • Monitoring included periodic brain scanning.

    • Main Results:

    • The patient initially treated with chloroquine phosphate developed three brain abscesses.
    • Prolonged combined therapy with metronidazole and chloroquine phosphate resulted in clinical improvement.
    • Periodic brain scanning indicated positive response to the extended treatment regimen.

    Conclusions:

    • Cerebral amebiasis should be suspected in patients with amebiasis (intestinal, hepatic, or pulmonary) presenting with neurological symptoms.
    • A prolonged course of combined metronidazole and chloroquine phosphate therapy may be effective for cerebral amebiasis.
    • Continuous monitoring with neuroimaging is recommended to assess treatment response.