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Monoclonal antibody mediated targeting of enzymes. A comparative study using the mouse spleen as a model system
N van Rooijen1, H ter Hart, G Kraal
1Department of Cell Biology, Medical Faculty, Vrije Universiteit, Amsterdam, Netherlands.
Journal of Immunological Methods
|July 6, 1992
Abstract:
The aim of this study was to target enzymes specifically to cells in the murine spleen. Monomeric and polymeric conjugates of the enzymes horseradish peroxidase or alkaline phosphatase and monoclonal antibodies against cell surface determinants were prepared. Highly specific in vivo targeting of enzymes to macrophages was obtained only when monomeric MAb-enzyme conjugates were used.
