The effects gastrin on neuromuscular activity

The effect of Pure Synthetic Human Gastrin-l (SHG-1) on the neuromuscular junction was studied using a rat phrenic nerve-hemidiaphragm preparation in an isolated organ bath connected to a four-channelled Physiograph recorder. It was found that Pure Synthetic human Gastrin-1 increased the skeletal muscular activity, with a mean rise of 15%/ (S.D. +/- 5.0) and N=10 x 10 for each figure. This action was found to be sustained for at least 60 minutes in all the experiments, and in this respect was different from the effect of potassium chloride on skeletal muscular activity. This new action of Gastrin has not been reported before, and further investigations are going on to elucidate the details of the mechanism of this action. We think that this action of gastrin will be found to be of great clinical significance.