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Related Experiment Videos

Elevated plasma RANTES levels in patients with atopic dermatitis.

H Yamada1, J Chihara, M Matsukura

  • 1Department of Dermatology, Kinki University, Osaka, Japan.

Journal of Clinical & Laboratory Immunology
|January 1, 1996
PubMed
Summary

Elevated RANTES levels were found in atopic dermatitis patients, particularly those with severe disease. This suggests RANTES may contribute to the recruitment and activation of immune cells in atopic dermatitis pathogenesis.

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Area of Science:

  • Immunology
  • Dermatology
  • Allergy Research

Background:

  • Atopic dermatitis involves eosinophils and T cells.
  • The role of RANTES (regulated on activation, normal T cell expressed and secreted) in atopic dermatitis pathogenesis is unclear.

Purpose of the Study:

  • To investigate the plasma levels of RANTES in patients with atopic dermatitis.
  • To explore the correlation between RANTES levels and disease severity.

Main Methods:

  • Plasma RANTES levels were quantified using sandwich ELISA.
  • Comparison was made between 11 atopic dermatitis patients and 15 healthy controls.

Main Results:

  • Mean plasma RANTES levels were significantly higher in atopic dermatitis patients compared to controls.

Related Experiment Videos

  • RANTES levels were elevated in patients with severe atopic dermatitis compared to those with mild disease.

    • Conclusions:

    • RANTES may play a role in the pathogenesis of atopic dermatitis.
    • RANTES could be involved in the recruitment and activation of eosinophils and T cells in this condition.