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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
07:02

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development

Published on: February 11, 2019

[Effect of esmolol on cardiovascular responses induced by scopolamine butylbromide]

Satomi Suzuki1, Akihiko Nonaka, Fumiaki Abe

  • 1Department of Anesthesia, Yamanashi Prefectural Central Hospital, Yamanashi 400-8506.

Masui. the Japanese Journal of Anesthesiology
|November 22, 2005
PubMed

Insights

Scopolamine butylbromide (HB) can increase heart rate. Esmolol effectively controlled this side effect during major abdominal surgery, preventing significant heart rate changes in patients receiving HB. This combination aids hemodynamic stability.

Area of Science:

  • Anesthesiology
  • Pharmacology

Context:

  • Scopolamine butylbromide (HB) is an anticholinergic smooth muscle relaxant used in surgery.
  • HB administration can cause a significant increase in heart rate as a side effect.
  • Hemodynamic management during major abdominal surgery requires careful monitoring.

Purpose:

  • To evaluate the efficacy of esmolol in mitigating the heart rate increase induced by scopolamine butylbromide (HB).
  • To assess the impact of esmolol on hemodynamic changes during major abdominal surgery under inhalation anesthesia.

Summary:

  • A randomized study compared esmolol (n=8) with a control group (n=9) receiving HB during major abdominal surgery.
  • While the control group showed a significant heart rate increase post-HB, the esmolol group maintained stable heart rates.
  • Neither group experienced significant changes in blood pressure.

Impact:

  • Simultaneous administration of esmolol and HB is effective for controlling heart rate elevations.
  • This combination can improve hemodynamic stability in patients undergoing major abdominal surgery.
  • Esmolol serves as a valuable adjunct for managing HB-induced tachycardia.
Abstract

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