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Updated: Aug 14, 2026
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
Published on: August 16, 2019
A systematic review of treatments for mild traumatic brain injury
P Comper1, S M Bisschop, N Carnide
1Toronto Rehabilitation Institute, University Centre, University of Toronto, ON, Canada. comper.paul@torontorehab.on.ca
Objectives:
To assess the effectiveness of interventions for mild traumatic brain injury (MTBI) in adults as found in the literature.
Research Design:
Systematic review of the literature.
Methods:
Six electronic databases and 18 journals within the brain injury field were manually searched between the years 1980-2003. References from articles were scanned for further literature. Studies that met broad inclusion criteria were subjected to a formal test of relevance. Those found to be relevant were qualitatively tested for their methodological soundness.
Results:
One thousand and fifty-five studies were initially identified and 163 were assessed using the relevance tool, yielding 20 studies for review. Four categories of interventions were identified: Pharmacotherapy, Cognitive Rehabilitation, Patient Education and Other. The majority of studies were weak, however there is evidence to support the effectiveness of patient education interventions.
Conclusions:
There are few rigorous studies evaluating treatment of MTBI. Limitations of the current literature are presented.
