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The calcium antagonists in vasospastic angina

R A Chahine1

  • 1University of Miami, Division of Cardiology, Miami, FL 33101, USA.

Journal of Cardiovascular Pharmacology
|January 1, 1991
PubMed

Insights

Calcium antagonists are the primary treatment for vasospastic angina. Amlodipine, a long-acting calcium antagonist, shows promise as a well-tolerated and effective option for managing this condition.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Coronary vasospasm is a key cause of angina at rest.
  • Calcium antagonists are established as the preferred treatment for vasospastic angina due to their vasodilatory properties.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of amlodipine in patients with vasospastic angina.
  • To assess the potential of amlodipine as a preferred calcium antagonist for this condition.

Main Methods:

  • Review of current literature on calcium antagonists for vasospastic angina.
  • Analysis of preliminary evidence regarding amlodipine's use in vasospastic angina.

Main Results:

  • Most available calcium antagonists are effective and safe for vasospastic angina.
  • Amlodipine is a long-acting dihydropyridine suitable for once-daily dosing.
  • Preliminary data suggest amlodipine is efficacious and well-tolerated.

Conclusions:

  • Amlodipine demonstrates potential as a preferred treatment for vasospastic angina.
  • Factors like duration of action and patient compliance are crucial in therapy selection.
  • Further evidence supports amlodipine's role in managing vasospastic angina.

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