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Biochronomer technology.

Jorge Heller1, John Barr

  • 1jorgeheller2@aol.com

Expert Opinion on Drug Delivery
|November 22, 2005
PubMed
Summary
This summary is machine-generated.

Biochronomer, a poly(ortho ester) polymer, offers controlled drug delivery. Its acid-labile nature enables rapid release of plasmid DNA for vaccines and other therapeutics.

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Area of Science:

  • Polymer chemistry
  • Biomaterials science
  • Drug delivery systems

Background:

  • Biochronomer is a fourth-generation poly(ortho ester) developed for controlled release applications.
  • The polymer's erosion rate is tunable via a copolymerized latent acid concentration.
  • Surface erosion is the primary degradation mechanism observed.

Purpose of the Study:

  • To explore applications of Biochronomer, focusing on plasmid DNA delivery for vaccines.
  • To leverage the polymer's acid-labile properties for targeted drug release.
  • To investigate its potential in clinical trials for pain and nausea management.

Main Methods:

  • Synthesis of poly(ortho ester) via condensation of diols and diketene acetal.
  • Incorporation of a latent acid for controlled hydrolysis.

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  • Evaluation of surface erosion and drug release kinetics.

    • Main Results:

    • Biochronomer demonstrates surface erosion, enabling controlled release.
    • Acid-labile hydrolysis facilitates rapid plasmid DNA release in acidic endosomal environments.
    • The polymer's non-acidic internal environment preserves plasmid DNA conformation.
    • Phase II trials for mepivacaine postoperative pain and Phase I trials for granisetron nausea are underway.

    Conclusions:

    • Biochronomer is a versatile poly(ortho ester) with significant potential in drug delivery.
    • Its tunable erosion and acid-triggered release properties are advantageous for vaccine and therapeutic applications.
    • Clinical trials indicate promise for managing postoperative pain and nausea.