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Oral pulsatile drug delivery systems.

Alessandra Maroni1, Lucia Zema, Matteo Cerea

  • 1Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Italy.

Expert Opinion on Drug Delivery
|November 22, 2005
PubMed
Summary

Pulsatile drug delivery systems offer programmable lag phases for oral administration. These systems are beneficial for chronotherapy of diseases with specific symptom timing, like asthma and angina.

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Growing interest in modified-release dosage forms.
  • Pulsatile delivery involves a programmable lag phase before drug release.
  • Potential benefits for chronotherapy of diseases with time-dependent symptoms.

Purpose of the Study:

  • To review rational and prominent design strategies for oral pulsatile drug delivery systems.

Main Methods:

  • Review of recent literature on pulsatile release systems.
  • Analysis of formulation approaches for delayed drug liberation.
  • Examination of single- and multiple-unit systems, capsular devices, and osmotic pumps.

Main Results:

  • Variety of pulsatile release systems reported for oral administration.
  • Systems designed for chronotherapy of conditions like asthma and angina.
  • Time-dependent colon delivery identified as a related application.

Conclusions:

  • Oral pulsatile delivery systems offer promising strategies for targeted drug release.
  • Formulation approaches like coatings, capsular devices, and osmotic pumps enable delayed liberation.
  • These systems are valuable for managing diseases with circadian symptom patterns.

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