Related Experiment Video
Updated: Aug 14, 2026

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
Published on: August 25, 2019
Chronopharmacology and controlled drug release
1University of Heidelberg, Institute of Pharmacology and Toxicology, Mannheim, Germany. bjoern.lemmer@urz.uni-heidelberg.de
Abstract:
Circadian rhythms in the body are well established and are an important factor to consider when administering drugs. Many diseases display symptoms and onset characteristics that are not randomly distributed within 24 h (e.g., coronary infarction, angina pectoris, asthmatic attacks and peptic ulcer perforations); therefore, it is not surprising that the effects and/or pharmacokinetics of drugs can display significant daily variations. Recent data, primarily concerned with the chronopharmacokinetics of antiasthmatics, histamine H2-blockers and cardiovascular active drugs (e.g., propanolol, organic nitrate and nifedipine) are described as representative examples in this review. The data demonstrate that biological rhythms should have been taken into account when evaluating drug delivery systems, galenic formulations and pharmacokinetics as a basis for drug treatment.
Related Concept Videos
Modified-Release Drug Delivery Systems: Classification
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Chronopharmacokinetics: Time-Dependent Pharmacokinetics
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
Oral Drug Delivery Systems: Continuous-Release Systems
Modified-Release Drug Delivery Systems: Rate-Programmed II
Modified-Release Drug Delivery Systems: Influencing Factors
