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Updated: Aug 14, 2026

Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Published on: March 25, 2015
Factors of importance for a successful delivery system for proteins
Marco van de Weert1, Lene Jorgensen, Eva Horn Moeller
1The Danish University of Pharmaceutical Sciences, Biomacromolecules Group, Department of Pharmaceutics and Analytical Chemistry, Copenhagen, Denmark. mvdw@dfuni.dk
Abstract:
Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
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