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Updated: Aug 14, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Molecular mechanisms regulating expression and function of transcription regulator inhibitor of differentiation 3
Robert Wai-Sui Lim1, Jin-Mei Wu
1Department of Medical Pharmacology and Physiology, University of Missouri-Columbia, Columbia, Missouri 65212, USA. limr@health.missouri.edu
Abstract:
The transcription factor antagonist inhibitor of differentiation 3 (Id3) has been implicated in many diverse developmental, physiological and pathophysiological processes. Its expression and function is subjected to many levels of complex regulation. This review summarizes the current understanding of these mechanisms and describes how they might be related to the diverse functions that have been attributed to the Id3 protein. Detailed understanding of these mechanisms should provide insights towards the development of therapeutic approaches to various diseases, including cancer and atherogenesis.
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