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Updated: Aug 14, 2026

Construction of Model Lipid Membranes Incorporating G-protein Coupled Receptors (GPCRs)
Published on: February 5, 2022
Two ligands for a GPCR, proton vs lysolipid
1Laboratory of Pharmacology and Research Institute of Drug Development, College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. imds@pusan.ac.kr
Abstract:
Recently, two different chemicals have been matched as ligands with the same G-protein-coupled receptor (GPCR). Double-pairing of OGR1 family GPCRs with proton and lysolipid raises several questions. First, whether both are the real ligands for the GPCRs. Second, whether modulation of a GPCR by two chemicals could be possible. Third, one of the chemicals is proton. Proton-sensing not only is a new action mode of GPCR activation, but also it could be generalized in other GPCRs. In this review, I would like to summarize the issue and discuss questions with pharmacological criteria.
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