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Nicotinamide adenine dinucleotide phosphate oxidase: a promiscuous therapeutic target for cardiovascular drugs?

Saima Muzaffar1, Nilima Shukla, Jamie Y Jeremy

  • 1Department of Cardiac Surgery, Bristol Heart Institute, Bristol Royal Infirmary, University of Bristol, BS2 8HW Bristol, UK.

Trends in Cardiovascular Medicine
|November 22, 2005
PubMed

Insights

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributes to cardiovascular diseases by producing superoxide. This review examines how common cardiovascular drugs affect NADPH oxidase activity and expression, offering therapeutic insights.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Pharmacology

Background:

  • Increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression and activity are implicated in cardiovascular disease etiology.
  • NADPH oxidase upregulation leads to superoxide formation, promoting vasculopathy.

Purpose of the Study:

  • To review drugs affecting NADPH oxidase activity and expression in cardiovascular medicine.
  • To discuss the mechanisms and therapeutic implications of these drug interactions.

Main Methods:

  • Literature review of drugs influencing NADPH oxidase.
  • Analysis of mechanisms of action on NADPH oxidase activity and expression.

Main Results:

  • Common cardiovascular drugs, including nitric oxide donors, nitroaspirin, eicosanoids, phosphodiesterase inhibitors, corticosteroids, antioxidants, and specific inhibitors, impact NADPH oxidase.
  • These drugs modulate NADPH oxidase at the level of expression and activity.

Conclusions:

  • Understanding drug effects on NADPH oxidase is crucial for cardiovascular disease management.
  • Targeting NADPH oxidase with specific drugs may offer novel therapeutic strategies.

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