Can symptom presentation predict unstable angina/non-ST-segment elevation myocardial infarction in a moderate-risk
Ann Comeau1, Louise Jensen, Jeffrey R Burton
1Cardiology, University of Alberta Hospital, Edmonton, Alberta, Canada.
Insights
Atypical symptoms are common in acute coronary syndromes (ACS), specifically unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI). Clinicians must consider these varied presentations for accurate diagnosis and timely treatment.
Area of Science:
- Cardiology
- Emergency Medicine
- Clinical Diagnosis
Background:
- Accurate recognition of acute coronary syndromes (ACS) is vital for reducing patient morbidity and mortality.
- The diverse symptom spectrum of ACS, particularly unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI), complicates early diagnosis.
- Patients with UA/NSTEMI often lack high-risk features, making symptom presentation the primary diagnostic clue.
Purpose of the Study:
- To compare typical versus atypical symptom presentation in patients with suspected UA/NSTEMI.
- To identify key differences in how patients present with UA/NSTEMI.
Main Methods:
- Prospective cohort study design.
- Evaluation of 100 patients within an Emergency Department Chest Pain Program.
- Analysis of symptom presentation in relation to UA/NSTEMI diagnosis.
Main Results:
- Atypical presentation was observed in the majority (74.2%) of UA/NSTEMI patients (n=23).
- While typical presentation was more likely to indicate UA/NSTEMI, atypical symptoms did not exclude the diagnosis.
- Male gender, symptom location, and prior ischemic heart disease history were associated with UA/NSTEMI.
Conclusions:
- Clinicians should not solely rely on classic angina descriptions for UA/NSTEMI diagnosis.
- Atypical symptom presentation is frequent in UA/NSTEMI and requires careful consideration.
- Diagnosis of UA/NSTEMI necessitates evaluating a broad range of patient symptoms.
Background:
Accurate recognition of acute coronary syndromes (ACS) on initial presentation is key to minimizing morbidity and mortality. The wide spectrum of symptom presentation in ACS complicates recognition. Unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI) may be particularly difficult to diagnose as patients often do not exhibit initial high-risk features, leaving the clinician with symptom presentation alone, on which to base decisions regarding further investigation and treatment.
Purpose:
The aim of this study was to compare typical symptom presentation (classic description of angina) and atypical presentation in a cohort presenting with symptoms suggestive of UA/NSTEMI.
Method:
A prospective cohort design was used to evaluate 100 patients enrolled in an Emergency Department Chest Pain Program.
Results:
Although patients with typical presentation were more likely to have UA/NSTEMI, atypical presentation did not rule out this diagnosis. Of the 31 patients with UA/NSTEMI, most (n=23, 74.2%) had atypical symptoms. Male gender, symptom location, and history of ischemic heart disease were significantly associated with UA/NSTEMI. Of those with a final diagnosis of UA/NSTEMI, there was no difference in symptom presentation based on age or gender.
Conclusion:
Clinicians should not rely on classic descriptions of angina when evaluating patients suspected of UA/NSTEMI.
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