Can symptom presentation predict unstable angina/non-ST-segment elevation myocardial infarction in a moderate-risk

Ann Comeau1, Louise Jensen, Jeffrey R Burton

  • 1Cardiology, University of Alberta Hospital, Edmonton, Alberta, Canada.

Insights

Atypical symptoms are common in acute coronary syndromes (ACS), specifically unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI). Clinicians must consider these varied presentations for accurate diagnosis and timely treatment.

Area of Science:

  • Cardiology
  • Emergency Medicine
  • Clinical Diagnosis

Background:

  • Accurate recognition of acute coronary syndromes (ACS) is vital for reducing patient morbidity and mortality.
  • The diverse symptom spectrum of ACS, particularly unstable angina/non-ST-elevation myocardial infarction (UA/NSTEMI), complicates early diagnosis.
  • Patients with UA/NSTEMI often lack high-risk features, making symptom presentation the primary diagnostic clue.

Purpose of the Study:

  • To compare typical versus atypical symptom presentation in patients with suspected UA/NSTEMI.
  • To identify key differences in how patients present with UA/NSTEMI.

Main Methods:

  • Prospective cohort study design.
  • Evaluation of 100 patients within an Emergency Department Chest Pain Program.
  • Analysis of symptom presentation in relation to UA/NSTEMI diagnosis.

Main Results:

  • Atypical presentation was observed in the majority (74.2%) of UA/NSTEMI patients (n=23).
  • While typical presentation was more likely to indicate UA/NSTEMI, atypical symptoms did not exclude the diagnosis.
  • Male gender, symptom location, and prior ischemic heart disease history were associated with UA/NSTEMI.

Conclusions:

  • Clinicians should not solely rely on classic angina descriptions for UA/NSTEMI diagnosis.
  • Atypical symptom presentation is frequent in UA/NSTEMI and requires careful consideration.
  • Diagnosis of UA/NSTEMI necessitates evaluating a broad range of patient symptoms.
Abstract

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