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Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
Published on: February 21, 2016
Chronic cyclosporine nephrotoxicity: a pig model
D Cibulskyte1, H Kaalund, M Pedersen
1Department of Renal Medicine, Aarhus University Hospital, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark. donataci@yahoo.com
Transplantation Proceedings
|November 22, 2005
Summary
This study investigated cyclosporine A (CsA) nephrotoxicity in pigs. Unexpectedly, pigs showed increased glomerular filtration rate (GFR) rather than kidney damage, suggesting a hyperfiltration response.
Area of Science:
- Nephrology
- Immunosuppression
- Animal Models
Background:
- Cyclosporine A (CsA) is crucial for immunosuppression post-transplant but causes nephrotoxicity.
- Reproducing chronic CsA nephrotoxicity in small animals is challenging.
Purpose of the Study:
- To evaluate chronic nephrotoxicity of therapeutic CsA dosages in a pig model.
- To assess the suitability of pigs for studying CsA-induced kidney effects.
Main Methods:
- 11 Gottingen minipigs received CsA (10 mg/kg/d) or placebo for 6 months.
- Monitored body weight, blood pressure, serum creatinine, CsA levels, and glomerular filtration rate (GFR).
- Renal biopsies were performed for histological analysis.
Main Results:
- Whole blood CsA trough levels were lower in pigs than in humans.
- No significant increase in serum creatinine or blood pressure was observed.
- A significant increase in GFR (hyperfiltration) was detected during CsA treatment, with no observable kidney histological changes.
Conclusions:
- The pig model did not replicate CsA-induced nephrotoxicity.
- Pigs exhibited a hyperfiltration response to CsA, requiring further investigation.
- This model may offer new insights into CsA's renal effects beyond toxicity.
