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Related Experiment Videos

Tolerance does not develop to the decrease in nicotine self-administration produced by repeated bupropion

Anthony S Rauhut1, Linda P Dwoskin, Michael T Bardo

  • 1Department of Psychology, Dickinson College, Carlisle, PA 17013, USA. rauhutta@dickinson.edu

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
|November 22, 2005
PubMed
Summary

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Repeated bupropion treatment significantly reduced nicotine self-administration in rats, suggesting a specific mechanism for smoking cessation. This animal model shows bupropion

Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • Bupropion is an effective smoking cessation aid, but its mechanism of action remains unclear.
  • Understanding bupropion's effects on nicotine intake is crucial for developing better smoking cessation therapies.

Purpose of the Study:

  • To investigate the effect of repeated bupropion administration on nicotine self-administration in rats.
  • To examine bupropion's impact on sucrose-maintained responding as a control for non-specific effects.

Main Methods:

  • Rats were trained to self-administer intravenous nicotine or respond for sucrose pellets.
  • Bupropion (70 mg/kg) or vehicle was administered subcutaneously 15 minutes before daily sessions for 14 days.
  • Changes in self-administration and responding were measured.

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Main Results:

  • Acute bupropion administration decreased both nicotine self-administration and sucrose responding by 60-70%.
  • Repeated bupropion pretreatment led to a complete cessation of nicotine self-administration.
  • The effect of bupropion on sucrose responding remained consistent with acute administration after repeated treatment.

Conclusions:

  • Repeated bupropion administration exhibits specificity in reducing nicotine intake, mimicking an extinction-like pattern.
  • These findings support bupropion's efficacy in smoking cessation and validate the rat nicotine self-administration model for evaluating cessation pharmacotherapies.