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Related Experiment Videos

Brain imaging in drug R&D.

Alex P Zijdenbos1, Jason P Lerch, Barry J Bedell

  • 1Neuralyse Inc., LaSalle, Canada. alex@bic.mni.mcgill.ca

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|November 22, 2005
PubMed
Summary
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Magnetic resonance imaging (MRI) is advancing drug development. New automated analysis and molecular MRI techniques offer non-invasive methods for detecting drug targets and analyzing brain structure and function.

Area of Science:

  • Neuroimaging
  • Pharmacology
  • Medical Imaging

Background:

  • Magnetic resonance imaging (MRI) has been a clinical diagnostic tool since the early 1980s.
  • MRI is increasingly integral to the drug development process.
  • Brain imaging research encompasses structure, function, acquisition techniques, and image processing.

Purpose of the Study:

  • To describe two advanced MRI methods for drug development.
  • To highlight automated morphometric analysis and molecular MRI.
  • To illustrate applications in neurological and oncological diseases.

Main Methods:

  • Development of a "pipeline" framework for automated brain imaging data analysis.
  • Exploration of molecular MRI for non-invasive molecular target detection.

Related Experiment Videos

  • Application of these techniques to study multiple sclerosis, Alzheimer's disease, and oncology.

    • Main Results:

    • The "pipeline" framework enables fully automated morphometric analysis of brain imaging data.
    • Molecular MRI shows promise for non-invasive detection of pharmacological compound targets.
    • These MRI advancements have potential applications in various disease areas.

    Conclusions:

    • Advanced MRI techniques, including automated analysis and molecular imaging, are valuable tools in drug development.
    • These methods offer new possibilities for understanding brain structure, function, and disease.
    • MRI applications in multiple sclerosis, Alzheimer's disease, and oncology are expanding.