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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Effective treatment of retrovirus-induced suppression of antibody responses with CpG oligodeoxynucleotides

Anke R M Kraft1, Tanja Arndt1, Kim J Hasenkrug2

  • 1Institut für Virologie des Universitätsklinikums Essen, Hufelandstrasse 55, 45122 Essen, Germany.

The Journal of General Virology
|November 22, 2005
PubMed

Most retroviruses induce severe immunosuppression during acute infection. We have used the Friend retrovirus mouse model to demonstrate that immunostimulatory B-type CpG oligodeoxynucleotides (ODN) have a protective effect against retrovirus-induced suppression of antibody responses to potent B-cell antigens. CD8+ T cells were critical for effective treatment with CpG-ODN, since in vivo depletion of these cells from treated mice impaired protection from retrovirus-induced immunosuppression. Protection also required IFN-gamma, as neutralization of this cytokine abolished the therapeutic effect of CpG-ODN. These findings may have implications for the treatment of immunosuppressive virus infections.

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