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Published on: July 26, 2019
Measles outbreak in the Republic of the Marshall Islands, 2003
Terri B Hyde1, Gustavo H Dayan, Justina R Langidrik
1Viral Vaccine Preventable Diseases Branch, National Immunization Program, NIP, Centers for Disease Control and Prevention, CDC, Atlanta, GA 30333, USA. thyde@cdc.gov
Background:
Measles is a highly contagious viral infection. Measles transmission can be prevented through high population immunity (>or=95%) achieved by measles vaccination. In the Republic of the Marshall Islands (RMI), no measles cases were reported during 1989-2002; however, a large measles outbreak occurred in 2003. Reported 1-dose measles vaccine coverage among children aged 12-23 months varied widely (52-94%) between 1990 and 2000.
Methods:
RMI is a Pacific island nation (1999 population: 50,840). A measles case was defined as fever, rash, and cough, or coryza, or conjunctivitis, in an RMI resident between July 13 and November 7, 2003. A vaccination campaign was used for outbreak control.
Results:
Of the 826 reported measles cases, 766 (92%) occurred in the capital (Majuro). There were 186 (23%) cases in infants aged <1 year and 309 (37%) of cases in persons aged >or=15 years. The attack rate was highest among infants (Majuro atoll: 213 cases/1,000 infants). Among cases aged 1-14 years, 281 (59%) reported no measles vaccination before July 2003. There were 100 hospitalizations and 3 deaths. The measles H1 genotype was identified. The vaccination campaign resulted in 93% coverage among persons aged 6 months to 40 years. Interpretation Populations without endemic measles transmission can accumulate substantial susceptibility and be at risk for large outbreaks when measles virus is imported. 'Islands' of measles susceptibility may develop in infants, adults, and any groups with low vaccine coverage. To prevent outbreaks, high population immunity must be sustained by maintaining and documenting high vaccine coverage.
Insights
A 2003 measles outbreak in the Republic of the Marshall Islands highlights the risk of measles in unvaccinated populations. High vaccination coverage is crucial to prevent future measles outbreaks.
Area of Science:
- Epidemiology
- Public Health
- Infectious Diseases
Background:
- Measles is a highly contagious viral infection preventable by vaccination.
- The Republic of the Marshall Islands (RMI) experienced a significant measles outbreak in 2003 after a period of no reported cases.
- Vaccine coverage in RMI varied significantly between 1990 and 2000, indicating potential pockets of susceptibility.
Purpose of the Study:
- To describe the epidemiology of the 2003 measles outbreak in the RMI.
- To identify risk factors and affected populations during the outbreak.
- To evaluate the effectiveness of the vaccination campaign for outbreak control.
Main Methods:
- A descriptive epidemiological study was conducted using reported measles cases in RMI from July to November 2003.
- Case definition included fever, rash, and respiratory or conjunctival symptoms.
- A vaccination campaign was implemented for outbreak control.
Main Results:
- A total of 826 measles cases were reported, with 92% concentrated in the capital, Majuro.
- Infants and individuals aged 15 years and older were significantly affected, with the highest attack rate among infants.
- Of measles cases aged 1-14 years, 59% were unvaccinated, and the outbreak resulted in 100 hospitalizations and 3 deaths.
Conclusions:
- Populations lacking endemic measles transmission can develop significant susceptibility, increasing outbreak risk upon virus introduction.
- Maintaining high vaccination coverage (>=95%) is essential to prevent measles outbreaks and protect vulnerable groups, including infants and adults.
- The vaccination campaign achieved 93% coverage, underscoring the importance of sustained public health interventions in maintaining herd immunity.
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