Related Experiment Video
Updated: Aug 14, 2026
Fast and Specific Assessment of the Halogenating Peroxidase Activity in Leukocyte-enriched Blood Samples
Published on: July 28, 2016
Eosinophils, but not eosinophil peroxidase or major basic protein, are important for host protection in experimental
Thirumalai Ramalingam1, Patricia Porte, James Lee
1Department of Pathology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3105, USA.
Abstract:
The attenuation of eosinophilia by the administration of monoclonal antibodies to CCR3 consistently correlates with impairment in worm elimination following primary intraperitoneal Brugia pahangi infections in mice. Host protection was unimpaired in mice deficient in eosinophil peroxidase (EPO) or major basic protein 1 (MBP-1), suggesting that eosinophils are essential in host protection but that neither EPO nor MBP-1 alone is.
