Periosteal chondromyxoid fibroma: a case study using imprint cytology

Bone surface is an exceptional location for chondromyxoid fibroma. Only 14 cases of juxtacortical chondromyxoid fibroma have been reported to date and, to our knowledge, none of these cases are documented with imprint cytology. We report a case of periosteal chondromyxoid fibroma located in the distal tibial metaphysis of a 4-yr-old boy. The clinical diagnosis was metaphyseal fibrous defect. Cytologic examination revealed a mixoid matrix, with stellate and spindle-shaped cells seen singly, focus of chondroid material, and epithelioid cells. Multinucleate giant cells were not seen. The diagnosis of periosteal chondromyxoid fibroma can be made by fine-needle aspiration or imprint cytology with clinico-radiologic correlation.