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Morpheaform extra-ocular sebaceous carcinoma.

D Innocenzi1, A Balzani, F Lupi

  • 1Dermatology and Plastic Surgery, University La Sapienza, Rome, Italy. daniele.innocenzi@uniroma1.it

Journal of Surgical Oncology
|November 22, 2005
PubMed
Summary
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Sebaceous carcinoma, a rare aggressive cancer, can present unusually. This case highlights a unique morpheaform presentation with no recurrence or metastasis after 15 years.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Sebaceous carcinoma is a rare, aggressive malignancy originating from sebaceous gland epithelium.
  • It can occur at ocular or extra-ocular sites, often presenting as a nodule.
  • Extra-ocular sebaceous carcinomas frequently metastasize and have a high mortality rate.

Observation:

  • A case report details a 68-year-old woman with a 15-year history of a morpheaform plaque on the upper lip.
  • Histological examination revealed marked stromal fibrosis.
  • The lesion extended into the left naso-genal groove.

Findings:

  • The patient's morpheaform presentation is histologically unusual, with only one prior reported case.
  • Remarkably, there were no signs of recurrence or metastasis 15 years after the initial tumor onset.

Related Experiment Videos

  • This contrasts with the typically aggressive nature and high mortality associated with extra-ocular sebaceous carcinomas.

    • Implications:

    • This case expands the understanding of sebaceous carcinoma's varied clinical and histological presentations.
    • Long-term favorable outcomes are possible even with unusual presentations.
    • Further research into factors influencing prognosis in rare sebaceous carcinoma subtypes is warranted.