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Pulmonary adenosquamous carcinoma in a dog
1Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanangawa 252-8510, Japan. t-sato@brs.nihon-u.ac.jp
Summary
A rare canine lung tumor, adenosquamous carcinoma, was identified in a dog. This mixed tumor showed features of both adenocarcinoma and squamous cell carcinoma.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Tumor Biology
Background:
- Lung masses in dogs can be challenging to diagnose.
- Understanding tumor heterogeneity is crucial for accurate pathology.
- This case examines a unique biphenotypic lung tumor in a canine patient.
Observation:
- A 10-year-old mixed-breed dog presented with a lung mass.
- Histopathology revealed a mixture of adenocarcinoma and squamous cell carcinoma components.
- Immunohistochemistry confirmed keratin expression in both tumor types.
Findings:
- The canine lung tumor was diagnosed as a primary adenosquamous carcinoma.
- Electron microscopy showed distinct cellular features for both glandular and squamous elements.
- The tumor exhibited phenotypic characteristics of both epidermal keratinocytes and glandular epithelium.
Implications:
- This case contributes to the understanding of rare canine lung neoplasms.
- Accurate diagnosis of adenosquamous carcinoma is essential for prognosis and treatment.
- Further research into canine biphenotypic tumors may improve diagnostic strategies.