[Antibacterial and immunocorrective therapy of diffuse purulent peritonitis]

The effectiveness of surgical treatment of 193 patients with generalized purulent peritonitis was analysed. The complex of bacteriologic and immunologic investigations contributed to optimization of antibacterial and immunocorrective therapy. Rational antibacterial therapy should be based on the principle of the use of broad and super-broad spectrum antibiotics with mandatory inclusion into the programme for treatment of metronidazole, administration of antibacterial agents before, at the time and after the operative intervention before identification of microflora and determination of its sensitivity to antibiotics. The therapeutic and tactical approach developed permitted to reduce lethality in generalized purulent peritonitis from 39.5 to 24.9%.